银杏达莫注射液治疗急性脑梗死随机对照试验的Meta分析

目的:系统评价银杏达莫注射液治疗急性脑梗死的疗效和安全性。方法:检索并选取国内、外公开发表的关于银杏达莫注射液治疗急性脑梗死随机对照试验文献,筛选合格研究,应用Jadad评分法进行质量评价,运用异质性检验、Meta分析、漏斗图分析等方法统计相关数据。结果:共有31项研究符合纳入标准。与对照组比较,银杏达莫注射液治疗急性脑梗死的神经功能缺损临床疗效比数比(OR)合并值为4.55(95%可信区间为3.63～5.70),神经功能缺损评分疗效加权均数差(WMD)合并值为—3.28(95%可信区间为—4.07～—2.49)。结论:Meta分析结果显示,银杏达莫注射液具有提高治疗急性脑梗死有效率、改善神经功能缺损的作用。

Meta - analysis on Random - control Experiment of Treatment of Acute Cerebral Infarction with Ginkgo Leaf Extract and Diphyridamole Injection

OBJECTIVE:To evaluate the curative effect and safety of Ginkgo leaf extract and diphyridamole injection in the treatment of acute cerebral infarction(ACI) with Meta analysis.METHODS:The literature both at home and broad about random-control clinical trials on Ginkgo leaf extract and diphyridamole injection for treating ACI were retrieved to screen the qualified researches.The Jadad score was used to evaluate the quality.The data were statistically analyzed by the differences examination,Meta analysis and funnel diagram analysis etc.RESULTS:31 researches accorded with the including criteria.Comparing with the control group,the treatment group had 4.55 Odds Ratio OR,95% confidence intervals(CI) was 3.63～5.70] and —3.28 weighted mean difference(WMD,95 % CI was —4.07～—2.49) in the neurologic impairment scores.CONCLUSION:Meta analysis displayed that Ginkgo leaf extract and diphyridamole injection is effective for ACI and it can improve the neurologic impairment in the treatment of ACI.