正交试验优选参芪颗粒干法制粒工艺

目的:优选参芪颗粒干法制粒工艺。方法:以一次成型率和溶化性为评价指标,以羧甲基淀粉钠、乙醇、聚维酮K30、乳糖分别与参芪浸膏粉的比例为考察因素,采用正交试验优选辅料配比;以一次成型率为评价指标,以轧辊压力、浸膏粉水分含量、轧辊转速、进料转速为考察因素,采用正交试验优选干法制粒工艺参数。结果:最佳辅料配比为加入参芪浸膏粉用量的0.05倍羧甲基淀粉钠、0.03倍乙醇、0.02倍乳糖;最佳制粒工艺为轧辊压力2.0MPa、浸膏粉水分含量2.0%、轧辊转速10r·min-1、进料转速14r·min-1。结论:所选工艺合理、可行,可用于制备参芪颗粒。

Optimization of Dry Granulation Technology for Shenqi Granules by Orthogonal Test

OBJECTIVE:To optimize the dry granulation technology of Shenqi granules. METHODS:The proportions of excip-ients were optimized by orthogonal test with once shaping rate and solubility as index using the proportions of carboxymethyl starchsodium(CMS-Na) ,ethanol,povidone K30 and lactose to Shenqi extract as factors;with once shaping rate as index,the orthogonaldesign was adopted to optimize the dry granulating technology for Shenqi granules using rolling pressure,moisture content of pow-dered extract,rolling speed and rotation rate of charge-in as factors. RESULTS:The optimal proportions of excipients were wereCMS-Na,ethanol,lactose were 0.05 times,0.03 times and 0.02 times higher than that of shenqi extract. The optimal dry granulationtechnology was as follows:rolling pressure of 2.0 MPa,moisture content of powdered extract of 2.0%,rolling speed of 10 r·min-1and rotation rate of charge-in of 14 r·min-1. CONCLUSION:The technology is reasonable and feasible,and can be used for thepreparation of Shenqi guranules.