中等剂量熊去氧胆酸治疗原发性胆汁性肝硬化的临床观察

目的:观察中等剂量熊去氧胆酸治疗原发性胆汁性肝硬化的临床疗效。方法:将临床196例原发性胆汁性肝硬化患者分为2组,对照组95例,采用常规对症疗法(保肝、解毒、利尿、抗菌);治疗组101例,在对症疗法的基础上加服中等剂量的熊去氧胆酸。2组均以1个月为1个疗程,3个疗程后观察2组治疗效果和肝功能检查结果。结果:3个疗程后,治疗组的总有效率(79.2%)显著高于对照组(60.0%),差异有统计学意义(P<0.01);肝功能检测结果显示,治疗组患者的丙氨酸氨基转移酶、天冬氨酸氨基转移酶显著降低(P<0.01),接近正常水平;谷酰转肽酶、碱性磷酸酶指标虽然没有恢复到正常范围,但与治疗前比较均有所降低(P<0.01)。结论:中等剂量熊去氧胆酸对原发性胆汁性肝硬化临床疗效显著。

Clinical Observation of Medium Dose of Ursodeoxycholic Acid for Primary Biliary Cirrhosis

OBJECTIVE:To observe clinical efficacy of moderate dose of ursodeoxycholic acid for primary biliary cirrhosis.METHODS:196 patients with primary biliary cirrhosis were divided into 2 groups.95 cases in the control group were given routine symptomatic therapy(liver protection,detoxification,diuretic,antibacterial).101 cases in treatment group were additionally given moderate dose of ursodeoxycholic acid on the basis of symptomatic therapy.A course of treatment lasted for 1 month.The therapeutic efficacy and liver function of 2 groups were investigated after 3 treatment courses.RESULTS:After 3 treatment courses,total effective rate of treatment group(79.2%) was significantly higher than that of control group(60.0%),there was statistical significance(P<0.01);Results of liver function test showed that ALT and AST of treatment group decreased significantly(P<0.01),was close to normal levels,GGB,ALT and TBA index hadn’t returned to normal range,but was lower than before treatment(P<0.01).CONCLUSION:The medium dose of ursodeoxycholic acid has obvious effect on primary biliary cirrhosis.