Antimicrobial activity of seven oral antibiotics against selected community- and hospital-acquired pathogens |
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Authors: | P R Murray |
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Institution: | Washington University School of Medicine, Barnes Hospital, St. Louis, Missouri. |
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Abstract: | The in vitro activity of seven oral antibiotics (ciprofloxacin, cephalexin, cefaclor, cefadroxil, cefuroxime, cefixime, and amoxicillin/clavulanate) was tested against 355 hospital-acquired pathogens and 342 community-acquired organisms. Whereas Staphylococcus aureus and Escherichia coli were the most common pathogens isolated in community-acquired infections, Enterobacter, Klebsiella, and Pseudomonas were isolated most frequently in hospital-acquired infections. All antibiotics with the exception of cefixime were active against the methicillin-susceptible staphylococci. Ciprofloxacin was the most active antibiotic against the members of the family Enterobacteriaceae and Pseudomonas. The community-acquired organisms tended to be more susceptible to antibiotics than the hospital-acquired organisms. Thus selection of oral antibiotics for the management of patients with hospital-acquired infections should be based on knowledge of the susceptibility patterns of hospital isolates. |
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