重症肌无力患者血清补体成分的测定

应用免疫扩散法测定55例重症肌无力（MG）患者和41例健康对照血清中补体（C1q、C3、C4、C9、C1－INH因子、B因子）的浓度。结果发现，MG患者G1－INH因子浓度明显高于健康对照组（P＜0．001）。而C1q和C9明显低于对照组（P＜0．001）；并且，随着受螺肌群的增加，C1q和C9有降低的趋势，而C1－INH因子有升高趋势；其它补体成分的浓度与对照组相比无显著性差异（P＞0．05）。16例MG初诊患者用药后，C9浓度显著升高（P＜0．001），C1q增高趋势有C1－INH因子下降趋势均明显，但三者均未恢复至正常水平（P＜0．01）。提示对MG患者测定血清补体，有助于进行动态观察，并可作为判断病情严重程度（活动性）的客观指标。

Measurement of complements in the sera of patients with myasthenia gravis

By using immune simple diffuse,the levels of the complements(C 1q ?C 3?C 4?C 9?C 1 INH factor?Bf)were measured in the sera from 55 MG patients and 41 controls Concentrations of C 9 and C 1q in MG patients were much lower than these in controls,while the concentration of C 1 INH rose significantly(P<0 001) With more skeletal muscles affected,both the tendency of the decline of C 9 and C 1q and that of the elevation of C 1 INH were more obvious The difference of the concentrations of the other complements between MG patients and controls had no statistical significance The levels of complements in the sera of 16 MG patients were also measured dynamically The concentration of C 9 significantly elevated after immune treatment(P<0 001),while the tendency of the decline of C 1 INH and the elevation of C 1q was obvious,all of them were not normal yet The test suggests that defecting of the levels of the complements in MG patients has attributions to mobile MG and maybe an objective index in determing the disease severity