急性脑梗死患者血清抗心磷脂抗体、D-二聚体水平及临床意义

目的：探讨急性脑梗死（acute cerebral infarction,ACI）血清抗心磷脂抗体（ACA）和D-二聚体水平及临床意义.方法：50例健康体检者为对照组,120例ACI患者为ACI组;ACI组根据ACA阳性与否分为ACA阳性组和ACA阴性组;ACI组再根据脑梗死是否复发分为初发组和复发组.测定各组血清中ACA、D-二聚体含量.结果：ACI组ACA阳性率为46.7％,高于对照组12.0％,差异有统计学意义（P＜0.01）;ACI组D-二聚体水平（0.92±0.38） mg/L,高于对照组（0.38±0.21） mg/L,差异有统计学意义（P＜0.01）.ACI组中ACA阳性组D-二聚体水平（1.35±0.31） mg/L,高于ACA阴性组（0.56±0.22）mg/L,差异有统计学意义（P＜0.01）;ACI复发组ACA阳性率为45.7％,高于初发组25.7％,差异有统计学意义（P＜0.01）.结论：血清ACA可能是脑梗死发生及复发的重要危险因素.

Serum anticardiolipin antibody and D-dimer of patients with acute cerebral infarction and its clinical significance

Objective： To detect the serum level of anticardiolipin antibody（ACA） and D-dimer and explore the relationship between ACA, D-dimer and acute cerebral infarction（ACI）. Methods. To measure serum ACA, D-dimer of 120 patients with acute cerebral infarction, and 50 healthy persons as control. ACI group was subdivided into primary group and relapse group. ACI group, ac cording to the ACA positive or not, were subdivided into positive group and negative group. ACI group, according to whether the recurrence of cerebral infarction, were divided into primary group and relapse group. Results： The ACA positive rate of ACI group was 46.7%, higher than 12% of the control group, the difference was statistically significant（P〈0.01）; ACI group D-dimer level （0.92±0.38）mg/L, higher than that of the control group（0.38±0.21）mg/L, the difference was statistically significant（P〈0. 01）. In the AO group, ACA positive group D-dimer level（1.35±0. 31）mg/L, higher than the ACA negative group（0.56±0.22）mg/L, the difference was statistically significant （P〈0.01） ; the positive rate of ACI recurrence group, ACA was 45.7%, higher than the primary group 25.7%, the difference was statistically significant（P〈0.01）. Conclusion： Serum ACA may be an important diagnostic marker of occurrence and recurrence of cerebral infarction.