肛置米索前列醇联合缩宫素预防产后出血的作用

目的：探讨直肠放置米索前列醇联合缩宫素预防产后出血的作用.方法：足月分娩、无高危因素的孕妇200例,随机进入,缩宫素组：100例,在胎儿前肩娩出后,立即静脉滴注缩宫素20U;米索前列醇组：100例,在胎儿娩出后,立即将米索前列醇400 μg置于产妇肛门内5 cm处,同时,静脉滴注缩宫素20 U,记录第三产程时间、产后2h内的出血量.结果：缩宫素组第三产程的时间（12.3±3.7）min,长于米索前列醇组的（8.6±4.0） min,有统计学意义（P＜0.05）.缩宫素组产后2h出血量（256.3±65.4）ml,多于米索前列醇组的（148.8±60.1）ml,差异有统计学意义（P＜0.05）.结论：米索前列醇联合缩宫素可缩短第三产程,减少产后出血.

Prevention of postpartum hemorrhage by combination of rectal misoprostol and oxytocin

Objective： To investigate the role of rectal misoprostol combined with oxytocin in preven ting postpartum hemorrhage. Methods： 200 women with term delivery and without risk factors were randomly divided into oxytocin group （n= 100） and misoprostol group （n= 100）. In oxytocin group, followed by delivery of fetal front shoulder, oxytocin （20 U） was immediately intravenously injected. In misoprostol group, after the baby was delivered, 400 μg misoprostol was immediately placed at 5 cm to maternal anus and then 20 U oxytocin was intravenously injected. The duration of the third stage of labor and the amount of bleeding within 2 hours after delivery were observed. Re suits： The third stage time of misoprostol group was （8.6±4.0）min that is shorter than that of oxytocin group （12.3±3.7）min（P〈0.05）. Meanwhile, combination of misoprostol and oxytocin sig nificantly reduced postpartum hemorrhage within 2 hours from （256.3±65.4）ml （oxytocin group） to （148.8±60.1）ml （P〈0.05）. Conclusion： Misoprostol combined with oxytocin can shorten the third stage of labor time and reduce postpartum hemorrhage.