| 葡萄糖转运子2在不同甲状腺功能状态大鼠肝脏中的变化 |
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| 引用本文： | 徐健,林汉华.葡萄糖转运子2在不同甲状腺功能状态大鼠肝脏中的变化[J].中华内分泌代谢杂志,2004,20(2):172-173. |
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| 作者姓名： | 徐健 林汉华 |
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| 作者单位： | 430030,武汉,华中科技大学同济医学院附属同济医院儿科 |
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| 摘 要： | 分别以左旋甲状腺素和他巴唑在Wistar大鼠制备甲状腺功能亢进 (甲亢 )和甲状腺功能减退 (甲减 )的动物模型。轻度和重度甲亢大鼠血糖、胰岛素和肝细胞膜葡萄糖转运子 2 (GLUT2 )水平均较对照大鼠明显升高 (P <0 .0 1或P <0 .0 5 )。甲减大鼠肝细胞膜GLUT2水平下降 (P <0 .0 5 )。结果提示 ,甲状腺功能状态明显影响实验动物的糖代谢。
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| 关 键 词： | 葡萄糖转运子2 甲状腺功能亢进症 甲状腺功能减退症 肝 大鼠 |
| 修稿时间： | 2002年10月24 |
Changes of glucose transporter 2 in rat livers under different status of thyroid function |
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| XU Jian,LIN Han-hua.Changes of glucose transporter 2 in rat livers under different status of thyroid function[J].Chinese Journal of Endocrinology and Metabolism,2004,20(2):172-173. |
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| Authors: | XU Jian LIN Han-hua |
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| Institution: | XU Jian,LIN Han-hua. Department of Pediatrics,Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430030 |
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| Abstract: | Models of hyperthyroidism and hypothyroidism were prepared in Wistar rats by levothyroxine and tapazole respectively. The levels of blood glucose, insulin and glucose transporter 2 (GLUT2) of hepatocytic membrane were higher in mild and severe hyperthyroid rats than those in control rats (P<0.05 or P<0.01). As compared with control rats, GLUT2 level of hepatocytic membrane was decreased (P<0.05) in hypothyroid rats. The results suggest that thyroid function significantly influenced glucose metabolism in experimental rats. |
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| Keywords: | Glucose transporter 2 Hyperthyroidism Hypothyroidism Liver Rats |
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