Flaxseed supplementation in non-alcoholic fatty liver disease: a pilot randomized,open labeled,controlled study |
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| Authors: | Zahra Yari Mehran Rahimlou Tannaz Eslamparast Naser Ebrahimi-Daryani Hossein Poustchi |
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| Institution: | 1. Department of Clinical Nutrition and Dietetics, Faculty of Nutrition and Food Technology, National Nutrition and Food Technology Research Institute, Shahid Beheshti University of Medical Science, Tehran, Iran;2. Department of Nutrition, Faculty of Nutrition and Dietetics, Tehran University of Medical Sciences, Tehran, Iran;3. Digestive Disease Research Institute, ImamKhomeini Hospital, Tehran University of Medical Sciences, Tehran, Iran;4. Liver and Pancreatobiliary Diseases Research Center, Digestive Diseases Research Institute, Tehran University of Medical Sciences, Tehran, Iran |
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| Abstract: | A two-arm randomized open labeled controlled clinical trial was conducted on 50 patients with non-alcoholic fatty liver disease (NAFLD). Participants were assigned to take either a lifestyle modification (LM), or LM?+30?g/day brown milled flaxseed for 12 weeks. At the end of the study, body weight, liver enzymes, insulin resistance and hepatic fibrosis and steatosis decreased significantly in both groups (pp?Pp p?p?=?0.013] and steatosis score ?47 compared with ?15.45?dB/m; p =?0.022]. In conclusion, flaxseed supplementation plus lifestyle modification is more effective than lifestyle modification alone for NAFLD management. |
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| Keywords: | Clinical trial flaxseed hepatic fibrosis liver enzymes non-alcoholic fatty liver disease |
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