5-HT1A receptor blockade reverses GABAA receptor α3 subunit-mediated anxiolytic effects on stress-induced hyperthermia |
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| Authors: | Christiaan H. Vinkers Ruud van Oorschot S. Mechiel Korte Berend Olivier Lucianne Groenink |
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| Affiliation: | (1) Division of Pharmacology, Utrecht Institute for Pharmaceutical Sciences and Rudolf Magnus Institute of Neuroscience, Utrecht University, Sorbonnelaan 16, 3584CA Utrecht, The Netherlands;(2) Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA |
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| Abstract: | Rationale Stress-related disorders are associated with dysfunction of both serotonergic and GABAergic pathways, and clinically effective anxiolytics act via both neurotransmitter systems. As there is evidence that the GABAA and the serotonin receptor system interact, a serotonergic component in the anxiolytic actions of benzodiazepines could be present. |
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