左乙拉西坦添加治疗难治性癫癎的临床观察

目的：观察左乙拉西坦（LEV）添加治疗难治性癫痫的临床疗效和安全性。方法：对32例难治性癫痫患者进行LEV添加治疗的开放性自身对照研究，观察疗效及不良反应3～12个月。结果：LEV添加治疗3月时总有效率达62．5％，无发作比例为18．75％，与基线比较有显著差异（P〈0．001），4～12月疗效与近期相仿。特发性癫痫和症状性癫痫总有效率无统计学差异。1年保留率为66．67％。3例出现体重增加、性格改变等不良反应，停药后消失。结论：LEV添加治疗难治性癫痫有良好疗效，且不良反应轻，保留率高。

Observation of Levetiracetam Add-on Therapy of Refractory Epilepsy

Objective:To evaluate the efficacy and safety of levetiracetam (LEV) as add-on therapy in the patients with refractory seizures. Methods: In this open add-on trial,LEV was applied additionally to the treatment of 32 patients with refractory epilepsy. The LEV treatment lasted for 3 to 12 months and the efficacy and side effects were assessed. Results: With three months’treatment,the effectiveness ratio (seizure frequency reduction ≥50%) was 62.50%,and seizure-free was observed in 6(18.75%)patients. LEV produced a significant difference when compared with the pre-LEV period (3 months baseline) (P<0.001).No significant overall clinical efficacy was found between patients with idiopathic epilepsy and those with symptomatic epilepsy after LEV treatment.The efficacy continued for 1 years in 66.67% patients. Three patients showed side effects such as weight increase and personality change that had disappeared after drug withdrawal.Conclusion: LEV is an effective antiepileptic drug for different seizure types.