肌成纤维细胞与颌骨放射性骨坏死

颌骨放射性骨坏死（osteoradionecrosis of jaw,ORNJ）是口腔颌面-头颈部恶性肿瘤放疗术后严重的并发症。迄今为止,其病因机制尚未完全明确,最新学说认为ORNJ是由放射诱导纤维萎缩机制形成,即放疗区域的软硬组织经放疗后发生一系列变化,形成病理性纤维化组织,最后,这些纤维化组织坏死崩解,导致ORNJ发生。肌成纤维细胞在肝、肺、肾及硬皮病等纤维化发生过程中起着重要作用,是否也在ORNJ过程中起着同样重要的作用还有待证实。本文就ORNJ病因机制学说,肌成纤维细胞的特征、肌成纤维细胞与成纤维细胞的联系及区别,肌成纤维细胞与ORNJ做一综述。

Myofibroblasts and osteoradionecrosis of jaw

ORNJ is a most severely complication of radiation therapy for head and neck cancer. Up to now, the precise pathogenesis of ORNJ has not been fully clarified, the newest one is radiation-induced fibrosis. It is believed that the hard and soft tissue of radiation area formed lots of pathologic fibrosis tissue through a series of changes after irradiation;subsequently, the pathological fibrous tissue disintegration caused ORNJ. Myofibroblasts play an important role in the fibrosis of liver, lung, kidney and scleroderma, whether it also plays an equally important role in ORNJ has yet to be confirmed. This paper mainly demonstrated the simple pathogenesis of ORNJ, the characteristics of the myofibroblasts,relationship and distinction between myofibroblasts and fibroblasts, and myofibroblasts and ORNJ.