榄香烯注射液联合单药长春瑞滨同步调强放疗治疗老年中晚期食管鳞癌的近期疗效

目的：观察榄香烯注射液联合单药长春瑞滨同步调强放疗治疗老年中晚期食管鳞癌的近期疗效和不良反应。方法80例老年食管鳞癌患者随机分为单纯调强放疗组（简称单放组）和榄香烯注射液联合单药长春瑞滨同步调强放疗组（联合组），每组各40例病人。两组患者调强放射治疗方法相同，放疗总剂量60~66 Gy。联合组每日放疗前2 h 予榄香烯200 mg 加入5%葡萄糖溶液100 ml 静脉滴注，长春瑞滨（ NVB）25 mg/m2，第1、8天，21天为一个周期，同步放疗连续化疗2周期。结果联合组患者近期有效率为92.5%，明显高于单放组的75%（P ﹤0.05），两组不良反应发生率无显著性差异。结论对于老年中晚期食管鳞癌患者，可采用榄香烯注射液联合单药长春瑞滨同步调强放疗的治疗方法，有较好的近期疗效，不良反应并未明显增加，远期疗效需进一步观察。

Clinical observition of Elemene injection and vinorelbine combined with IMRT for elder patients with advanced esophageal squamous cell carcinoma

Objective：To investigate the efficacy and side effects of elemene injection and vinorelbine combined with Intensity Modulated Radiation Therapy（IMRT）treatment for elder patients with advanced squamous cell carcinoma. Meth-ods：Eighty elder patients with advanced esophageal squamous cell carcinoma were randomly divided into pure intensity modulated radiotherapy（ radiation group ）and elemene injection with vinorelbine combined with IMRT group（combination group）,with 40 patients in each group. Intensity modulation radiotherapy was applied in the two groups of patients with a total dose of 60 ~ 66Gy. Combination group were injected with elemene injection（200mg elemene was dissolved in 5% glu-cose solution 100 mL）before radiotherapy every day intravenously,vinorelbine（NVB）was given 25 mg / m 2 on d1 and d8 with 21 days as a cycle for 2 cycles. Results：In the combination group,the effective rate was 92. 5% ,while that of ra-diation group was 75% . The effective rates of the two groups had statistic significances（χ2 = 4. 501,P ﹤ 0. 05）. The major adverse effects in the two groups had no significant difference. Conclusion：For elder patients with advanced esophageal squamous cell carcinoma,Elemene injection and vinorelbine combined with IMRT can improve their recent effective rates, the adverse effects can be accepted and the long - term effects need to be further observed.