虎杖膏外敷预防甘露醇所致兔耳浅静脉损伤的实验研究

目的:探讨虎杖膏对甘露醇所致浅静脉损伤的最佳防护时机。方法:将24只新西兰成年大耳白兔随机分为实验组和对照组,每组12只。采用20%的甘露醇制作静脉留置针动物模型,两组分别在输注甘露醇前30 min及输注甘露醇时外敷虎杖膏,在连续给药5 d后通过肉眼观察及光镜下分析评价各组静脉及周围组织病理损伤程度,比较实施防护的效果。结果:实验组耳静脉炎发生率低于对照组(P0.05),血管内皮肿胀、血管周围水肿、炎细胞浸润程度低于对照组(P0.05)。结论:输注甘露醇前30 min实施虎杖膏外敷是预防浅静脉损伤的最佳防护时机。

Study on the test of giant knotweed cream prevention of mannitol-inducedrabbit ear superficial venous injury

Objective： To study the optimal timing of giant knotweed cream on prevention of mannitol- induced superficial venous injury. Methods： 24 adult New Zealand rabbits were randomly divided into two groups,with 12 in each group. All the rabbits were injected with 20% mannitol solution into the ear vein to build up animal models of experimental phlebitis. Then the test group respectively received topical giant knotweed cream 30 minutes before the infusion of mannitol and the control group received giant knotweed cream during the infusion of mannitol. Pathological damage of ear veins and the peripheral tissue of all rabbits were analyzed and evaluated after 5 days through naked eyes and a microscope,compared the effect of the implementation of the protection. Results： The ear phlebitis incidence of test group was lower than the control group（ P〈0. 05）. Degree of pathological damage of vascular endothelial swelling, edema,inflammatory cells infiltration of test group were all lower than the control group（ P 〈 0. 05）. Conclusion： 30 minutes before infusion of mannitol implementation giant knotweed cream is the best protection timing on prevention of superficial venous injury.