全反式维甲酸、化疗及白血康序贯治疗急性早幼粒细胞白血病疗效观察

目的:观察全反式维甲酸、联合化疗及白血康序贯治疗急性早幼粒细胞白血病的疗效和副作用。方法:对经诱导达完全缓解的41例急性早幼粒细胞白血病(APL)患者,停药4周后采用HA、DA或MA方案巩固治疗,间歇4周后,给予口服白血康胶囊28天;再间歇4周给予口服全反式维甲酸28天,为1个周期。间歇4周再重复以上周期。完全缓解后第1年每疗程间隔1个月,第2年每疗程间隔2个月,第3年3个月。结果:45例APL患者诱导缓解后41例达完全缓解,40例参与序贯治疗者,3年和5年DFS和OS均为96.7%,毒副作用轻。结论:应用全反式维甲酸、联合化疗及白血康序贯治疗急性早幼粒细胞白血病,3年和5年DFS和OS均明显提高,这一新的联合治疗方案有可能使APL成为通过非骨髓移植手段获得治愈的白血病。

Curative effects of sequential therapy with all -trans retinoic acid, combined with chemotherapy and Bai- Xue- kang capsules on acute promylocytic leukemia

Objective:To observe the curative effect and side effects of sequential therapy with all-trans retinoic acid,combined with chemotherapy and Bai-Xue-kang capsules on acute promylocytic leukemia(APL)patients.Methods:Total of 41 APL patients who had reached complete remission(CR)received combined with chemotherapy of HA,DA,or MA,then Bai-Xue-kang capsures for 28 days,and all-trans retinoic acid for 28 days one by one at 4 weeks interval respectively.Above sequential treatment termed a therapeutic circled over the first year,then the interval between each treatment was extended to 8 weeks in the second year,12 weeks in third year.Results:The CR rate of 41 APL patients after remission induction was 91.11%.DFS and OS of 3 years and 5 years for 40 APL patients received sequential treatment were both 96.7%,while side effects were mild.Conclusion:With sequential therapy of all-trans retinoic acid,combined with chemotherapy and Bai-Xue-kang capsules,DFS and OS of 3 years and 5 years for 40 APL patients increased significantly.This novel strategy of combined treatment maybe make APL becomes the most probably healing-well leukemia through non-transplantation therapy.