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In vivo efficacy of aerosolized nanostructured itraconazole formulations for prevention of invasive pulmonary aspergillosis |
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| Authors: | Hoeben Barbara J Burgess David S McConville Jason T Najvar Laura K Talbert Robert L Peters Jay I Wiederhold Nathan P Frei Bradi L Graybill John R Bocanegra Rosie Overhoff Kirk A Sinswat Prapasri Johnston Keith P Williams Robert O |
| Affiliation: | University of Texas Health at Austin College of Pharmacy, TX, USA. |
| Abstract: | Aerosolized evaporative precipitation into aqueous solution and spray freezing into liquid nanostructured formulations of itraconazole as prophylaxis significantly improved survival relative to commercial itraconazole oral solution and the control in a murine model of invasive pulmonary aspergillosis. Aerosolized administration of nanostructured formulations also achieved high lung tissue concentrations while limiting systemic exposure. |
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