Induction of calcium influx in immature T lymphocytes by anti-FT-1 monoclonal antibody |
| |
| Authors: | M Kasai T Kataoka T Tokunaga |
| |
| Institution: | Department of Cellular Immunology, National Institute of Health, Tokyo, Japan. |
| |
| Abstract: | The functional role of FT-1 antigen was investigated by measuring changes in intracellular Ca2+]i after the addition of anti-FT-1 monoclonal antibody to murine T leukemic cells and embryonic thymocytes. Anti-FT-1 induced a rapid and sustained increase in cytosolic free Ca2+]i and this effect was completely blocked by EGTA and La3+. These results suggest that FT-1 molecule is functionally associated with a plasma membrane calcium ion channel in embryonic thymocytes. |
| |
| Keywords: | |
| 本文献已被 ScienceDirect 等数据库收录！ |
