热休克蛋白60在激活的少突胶质前体细胞的表达 |
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引用本文: | 李云鸿;齐奇;滕鹏;成文静;马骄;张楠;丁斐嘉;李凡;苗珍花;黄卫东;沈颖;王银.热休克蛋白60在激活的少突胶质前体细胞的表达[J].宁夏医科大学学报,2013(9):960-963,948. |
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作者姓名: | 李云鸿;齐奇;滕鹏;成文静;马骄;张楠;丁斐嘉;李凡;苗珍花;黄卫东;沈颖;王银 |
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作者单位: | 宁夏医科大学;浙江大学医学部神经生物学系 |
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基金项目: | 国家自然科学基金项目(31260243,31060140);教育部新世纪优秀人才支持计划和留学回国人员基金 |
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摘 要: | 目的研究热休克蛋白60(HSP60)在重组人干扰素-γ(IFN-γ)和重组人热休克蛋白60(rhHSP60)激活的少突胶质前体细胞中的表达情况。方法分离SD大鼠的少突胶质细胞前体细胞(OPC),经IFN-γ和rhHSP60激活后,应用western blot方法检测细胞中的HSP60蛋白的表达;采用ELISA方法检测细胞培养液中炎症因子TNF-α及IL-6的释放量。结果经IFN-γ和rhHSP60分别激活后,OPC胞体内的HSP60蛋白表达均显著升高,胞外TNF-α及IL-6的释放量也明显增加。结论在激活状态下,OPC中的HSP60蛋白表达显著增高,刺激细胞产生大量炎症因子,从而参与细胞的应激反应。
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关 键 词: | 热休克蛋白60 少突胶质细胞前体细胞 重组人干扰素-γ 重组人热休克蛋白60 |
Expression of HSP60 in Activated OPC |
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Affiliation: | LI Yunhong;QI Qi;TENG Peng;CHENG Wenjing;MA Jiao;ZHANG Nan;DING Feijia;LI Fan;MIAO Zhenhua;HUANG Weidong;SHEN Ying;WANG Yin;Ningxia Medical University; |
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Abstract: | Objective To explore the expression of HSP60 in IFN- γ and rhHSP60 activated OPC. Methods After OPC were treated with IFN- γ and rhHSP60,cells were collected for western- blot. The release of TNF- α and IL- 6 were detected by ELISA in the supernatant. Results In IFN- γ and rhHSP60 activated OPC,HSP60 protein significantly increased and stimulated the production of amount of cytokines such as TNF- α and IL- 6 compared to control. Conclusion In activated OPC,HSP60 highly expressed to participate the stress response. |
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Keywords: | HSP60 OPC IFN-γ rhHSP60 |
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