宁夏社区人群冠心病家族史与缺血性心电图异常的关系

目的探讨冠心病家族史与缺血性心电图异常的关系,为缺血性冠心病防治提供理论依据。方法利用卫生部疾病控制项目"全国高血压规范化管理"和卫生部行业基金项目"心血管病危险因素监测和高血压规范化管理"中宁夏分中心的基线资料进行分析,共2250名志愿参加且资料完整的社区人群的数据纳入分析。结果随着年龄的增加,回答"不清楚父亲或母亲有冠心病"的比例均显著增加,确定"父母均无冠心病史"的比例显著增加(P<0.05)。<50岁人群,具有冠心病家族史的人群比无家族史人群心电图异常检出率显著增高(17.2%vs 9.5%,P<0.05);≥50岁人群,冠心病家族史对心电图异常的影响不显著(P>0.05)。BMI、血压水平、总胆固醇水平均为有冠心病家族史人群显著高于无冠心病家族史人群,且50岁上、下年龄组结果相似。Logistic回归分析结果显示,冠心病家族史可以显著增加心电图异常的风险(OR=1.51,95%CI=1.09～2.10);剔除50岁以上的人群进行敏感度分析,结果显示冠心病家族史依然是心电图异常的独立风险因素且作用增强。结论冠心病家族史是心电图异常的独立危险因素,尤其是低年龄组人群中作用更显著。

The Relationship between CAD Family History and the Abnormal CHD-related ECG among 2520 Cases with Hypertensio in Ningxia

Objective To explore the relationship between the CAD family history and CHD-related ECG abnormalities.Methods The baseline data of 2524 cases with hypertension who entered "Disease Control Project of the Ministry-National standardized management on High Blood Pressure" and "the Ministry of Health Industry Fund-cardiovascular disease risk factor surveillance and high blood pressure standardized management" in the Ningxia were analyzed.Results The proportion of answering "unclear" for family history of coronary heart disease significantly increased with age while "clear" significantly reduced with age(P<0.05).The rate of abnormal ECG in cases under 50 years old with positive family history of CHD was significantly higher than that in cases with negative family history of CHD(17.2% vs 9.5%,P<0.05).The rate of abnormal ECG showed no significant difference between different family history of CHD in cases aged above 50(P>0.05).Cases with positive family history of CHD had significantly higher BMI,blood pressure,and TC than the cases with negative family history of CHD had.Logistic regression analysis showed that the family history of CHD significantly increased the risk of abnormal ECG(OR=1.51,95%CI=1.09-2.10).Furthermore,after excluding the people above 50 age old,the family history of CHD was the independent risk factor of abnormal ECG.Conclusion Family history of CHD was the independent risk factor of abnormal ECG,especially in cases aged under 50.