| 正交试验法优选四妙颗粒的提取工艺 |
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| 引用本文： | 李文,李俭,陆晓梅. 正交试验法优选四妙颗粒的提取工艺[J]. 中国药业, 2005, 14(12): 56-57 |
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| 作者姓名： | 李文 李俭 陆晓梅 |
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| 作者单位： | 1. 江苏省南京市中医院,江苏,南京,210001
2. 南京中医药大学,江苏,南京,210018 |
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| 摘 要： | 目的:优选四妙颗粒中盐酸小檗碱的提取方法.方法:以四妙颗粒中盐酸小檗碱为指标,用高效液相色谱法进行分析测定,系统考察不同浓度、体积的乙醇以及不同提取次数对盐酸小檗碱提取率的影响,并用正交试验法进一步优选提取条件.结果:最佳提取工艺条件为7倍量、75%乙醇回流提取3次.结论:提取次数对盐酸小檗碱的提取率有较大影响,优选工艺可行.
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| 关 键 词： | 四妙颗粒 盐酸小檗碱 提取工艺 正交试验 |
| 文章编号： | 1006-4931（2005）12-0056-02 |
| 收稿时间： | 2004-12-22 |
| 修稿时间： | 2005-04-01 |
Optimal Extraction of Simiao Granules Established by Orthogonal Test |
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| Li Wen,Li Jian,Lu Xiaomei. Optimal Extraction of Simiao Granules Established by Orthogonal Test[J]. China Pharmaceuticals, 2005, 14(12): 56-57 |
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| Authors: | Li Wen Li Jian Lu Xiaomei |
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| Abstract: | Objective:To establish an extraction method of berberine hydrochloride in Simiao granules.Methods:Berberine hydrochloride in Simiao granules was taken as an evaluating marker and determined by HPLC.The effects of different percent and different volume of alcohol and the times of extraction on extraction ratio of the berberine hydrochloride were systematically investigated.And also the orthogonal test was further used to optimize extracting conditions.Results:The refiuent extraction with 75% alcohol as seven times of the medicine amount for Ih and three times was more effective.Conclusion:The times of extraction has a great influence upon the extracting efficiency of berberine hydrochloride. |
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| Keywords: | simiao granules berberine hydrochloride HPLC orthogonal test |
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