| 端粒、端粒酶及其亚单位在鼻咽癌中相互作用的研究 |
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| 引用本文： | 文忠,肖健云,田勇泉,赵素萍,郭梦和. 端粒、端粒酶及其亚单位在鼻咽癌中相互作用的研究[J]. 肿瘤防治研究, 2002, 29(4): 298-300 |
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| 作者姓名： | 文忠 肖健云 田勇泉 赵素萍 郭梦和 |
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| 作者单位： | 1. 510282,广州第一军医大学珠江医院耳鼻咽喉科
2. 长沙中南大学湘雅一医院耳鼻咽喉科 |
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| 摘 要： | 目的 探讨端粒、端粒酶及其亚单位在鼻咽癌发病中的作用。方法 采用Southern杂交等分子生物学方法对鼻咽癌端粒、端粒酶及其亚单位进行检测。结果 鼻咽癌平均端粒长度 (MTL)为 4 .5± 2 .3kb ,端粒酶阳性表达为 88.0 %～ 10 0 %。对照组MTL分别为 14 .6± 2 .8Kb和 15 .8± 3.8Kb ,癌旁组织端粒酶阳性表达为 6 4.7% ,对照组为 0～ 8.7%。此外 ,端粒酶活性增高与晚期鼻咽癌及其颈淋巴结转移也有密切关系。结论 端粒及端粒酶与鼻咽癌的发生、发展及转移可能有密切关系
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| 关 键 词： | 癌 鼻咽的 端粒 端粒酶 端粒酶亚单位 |
| 文章编号： | 1000-8578(2002)04-0298-03 |
| 收稿时间： | 2001-02-06 |
| 修稿时间： | 2001-02-06 |
The role of telomere, telomerase and its hTR in nasopharyngeal carcinoma |
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| WEN ZHong,XIAO Jian|yun,TIAN Yong|quan,et al. The role of telomere, telomerase and its hTR in nasopharyngeal carcinoma[J]. Cancer Research on Prevention and Treatment, 2002, 29(4): 298-300 |
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| Authors: | WEN ZHong XIAO Jian|yun TIAN Yong|quan et al |
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| Affiliation: | WEN ZHong,XIAO Jian|yun,TIAN Yong|quan,et al Department of ENT,Pearl River Hospital,The First Military Medical University,Guangzhou 510282,China |
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| Abstract: | Objective To explore the role of telomere, telomerase and its hTR in NPC.Methods The telomere kinetic, The expressions of telomerase and its hTR were studied with Southern Blot, TRAP PCR ELISA and RT nested|PCR, respectively.Results There were shorter MTL (4.5±2.3kb) and higher telomerase activity (88.0%) in nasopharyngeal tissues as compared with normal control. High expression of telomerase was also noticed in the adjacent tissues( 64.7%). Telomerase activities were also related to the late stage carc... |
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| Keywords: | Carcinoma Nasopharyngeal Telomere Telomerase Telomerase subunit |
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