Interaction of secreted phospholipase A2 and Pulmonary surfactant and its pathophysiological relevance in acute respiratory distress svndrome

Phospholipases A_2(PLA_2s)belong to a family of enzymes that hydrolyze phospholipids at the sn-2 position leading to the liberation of fatty acids and lysophospholipids(Fig 1). Mammaliall PLA_2s are divided into two major classes according to their location: high molecular mass intracellular PLA_2 and low molecular mass secreted PLA_2(sPLA_2)(Fig 2). There have been Substantial progresses in understanding the regulation of sPLA_2 expression. especiallv the type-ⅡA sPLA_2