Theophylline is able to partially revert cachexia in tumour-bearing rats |
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Authors: | Mireia Olivan Jochen Springer Sílvia Busquets Anika Tschirner Maite Figueras Miriam Toledo Cibely Fontes-Oliveira Maria Inés Genovese Paula Ventura da Silva Angelica Sette Francisco J López-Soriano Stefan Anker Josep M Argilés |
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Affiliation: | 1. Cancer Research Group, Departament de Bioqu??mica i Biologia Molecular, Facultat de Biologia, Universitat de Barcelona, Diagonal 645, Barcelona, 08028, Spain 3. Division of Applied Cachexia Research, Department of Cardiology, Charit?? Medical School, Berlin, Germany 2. Institut de Biomedicina de la Universitat de Barcelona, Barcelona, Spain
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Abstract: | ABSTRACT: Background and aims: The aim of the present investigation was to examine the anti-wasting effects of theophylline (a methylxantine present in tea leaves) on a rat model of cancer cachexia. Methods: the in vitro effects of the nutraceuticals on proteolysis were examined on muscle cell cultures submitted to hyperthermia. Individual muscle weights, muscle gene expression, body composition and cardiac function were measured in rats bearing the Yoshida AH-130 ascites hepatoma, following theophylline treatment. Results: Theophylline treatment inhibited proteolysis in C2C12 cell line and resulted in an anti-proteolytic effect on muscle tissue (soleus and heart), which was associated with a decrease in circulating TNF-alpha levels and with a decreased proteolytic systems gene expression. Treatment with the nutraceutical also resulted in an improvement in body composition and cardiac function. Conclusion: Theophylline - alone or in combination with drugs - may be a candidate molecule for the treatment of cancer cachexia. |
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