Possible interaction of cholinergic and GABAergic systems between MS and CA1 upon memory acquisition in rats |
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Authors: | Behnam Yousefi Mohammad Nasehi Fatemeh Khakpai Mohammad Reza Zarrindast |
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Institution: | Department of Neuroscience, School of Advance Medical Technologies, Tehran, Iran. |
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Abstract: | The present study explored the possibility that cholinergic and GABAergic systems of medial septum (MS) might influence acquisition of memory by regulation of acetylcholine (Ach) and γ-aminobutyric acid (GABA) receptors function in hippocampus and vice versa. The step-through passive avoidance (PA) task was used. The results showed that pre-training intra-MS/CA1 administration of nonselective muscarinic Ach antagonist, scopolamine (0.5, 1 and 2μg/rat) and GABA(A) receptor agonist, muscimol (0.01 and 0.02μg/rat) impaired, while acetylcholinesterase inhibitor, physostigmine (0.5 and 1μg/rat) and GABA(A) receptor antagonist, bicuculline (0.25μg/rat) improved memory acquisition. Moreover, intra-CA1/MS administration of a subthreshold dose of muscimol or bicuculline increased and reversed the impairment induced by scopolamine in MS/CA1 respectively (cross injection). Also, the result revealed that, intra-CA1/MS administration subthreshold dose of muscimol reduced improvement of memory induced by physostigmine in the MS/CA1, respectively (cross injection). On the other hand, subthreshold dose of bicuculline in CA1/MS did not alter memory improvement induced by physostigmine in the other site (MS/CA1). In conclusion, both cholinergic and GABAergic systems not only seem to play a role in the modulation of memory in the MS and CA1 but also to have a complex interaction. |
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