Vaccine prospects of killed but metabolically active Leishmania against visceral leishmaniasis |
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Authors: | Amrita Das Nahid Ali |
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Affiliation: | Infectious Diseases and Immunology Division, Indian Institute of Chemical Biology, 4 Raja S.C. Mullick Road, Jadavpur, Kolkata 700032, India. |
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Abstract: | Leishmanization or live vaccination, the gold standard for immunoprophylactic success against cutaneous leishmaniasis, has been abandoned for safety reasons. Killed but metabolically active (KBMA) Leishmania, a new class of whole-cell vaccine, holds promise for safe vaccination. Amotosalen (S-59)-treated and UVA-irradiated Leishmania major and Leishmania infantum chagasi (KBMA-Lic) were rendered replication-incompetent and incapable of causing disease; this was demonstrated convincingly by sensitive techniques. However, the immune response and the level of protection elicited by vaccination with both live Lic and KBMA-Lic in BALB/c mice are less than optimal and warrant further studies to establish their potentiality as an effective vaccine strategy against visceral leishmaniasis. |
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