Cyclodextrin, a probe for studying adhesive interactions |
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Authors: | Sajadi Sahar Rojas Patricia Oppenheimer Steven B |
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Affiliation: | Department of Biology and Center for Cancer Developmental Biology, California State University Northridge, 18111 Nordhoff Street, Northridge, CA 91330-8303, USA. |
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Abstract: | In this short communication, we introduce alpha-cyclodextrin as a new probe to study mechanisms of adhesive interactions. We show that this cyclic polysaccharide, that consisting of six glucosyl residues linked by alpha-1,4 bonds, was the only sugar of 22 tested that dramatically blocked a specific cellular interaction in the sea urchin embryo (p<0.001 compared with non-sugar controls). A total of 150-400 embryos were sampled for each concentration of each sugar tested. Mechanisms of cellular interactions have been studied for almost a century and they still remain poorly understood. Cyclodextrin is an exciting new tool that can be utilized for investigating these mechanisms. |
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Keywords: | Alpha cyclodextrin Sea urchin adhesive interactions |
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