| 双丹组分对大鼠离体血管和急性心肌缺血再灌注损伤的影响 |
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| 引用本文： | 靳康,阚红卫,石静丽,王海青,徐鹏夫,梁燕,杨士友,田军.双丹组分对大鼠离体血管和急性心肌缺血再灌注损伤的影响[J].中国实验方剂学杂志,2010,16(17):197-201. |
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| 作者姓名： | 靳康 阚红卫 石静丽 王海青 徐鹏夫 梁燕 杨士友 田军 |
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| 作者单位： | 1. 安徽省药物研究所药理室,安徽省药品临床前安全评价中心,安徽省中药研究与开发重点试验室,合肥,230022;安徽大学生命科学学院,合肥,230023
2. 安徽省药物研究所药理室,安徽省药品临床前安全评价中心,安徽省中药研究与开发重点试验室,合肥,230022 |
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| 摘 要： | 目的:观察丹酚酸B和丹皮酚不同配比组合对大鼠离体胸主动脉血管的舒张作用和急性心肌缺血再灌注损伤的保护作用。方法:采用基线等比增减设计法进行药物配比设计,观察不同配比组合对去甲肾上腺素、氯化钾诱导的大鼠收缩血管环的舒张效应;结扎心脏左冠状动脉前降支(LAD)制备急性心肌缺血再灌注损伤模型,观察不同药物组合对心电图(ECG)、心肌梗死面积(MIS)、血清丙二醛(MDA)、一氧化氮(NO)、超氧化物歧化酶(SOD)和肌酸激酶同工酶(CK-MB)的影响。结果:丹酚酸B和丹皮酚各配比组合对离体血管舒张效果明显高于模型组,可减少再灌注损伤造成的心肌梗死面积,降低缺血程度(∑-ST),提高血清中SOD活力和NO含量,降低MDA含量和CK-MB水平;不同组合以丹酚酸B和丹皮酚之比为3∶1药物组合效果最佳。结论:丹酚酸B和丹皮酚配比组合对大鼠血管具有一定的舒张作用以及对大鼠急性心肌缺血再灌注损伤具有较好的保护作用,丹酚酸B和丹皮酚之间可能存在一定的协同或相加作用。
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| 关 键 词： | 丹酚酸B 丹皮酚 心肌缺血再灌注损伤 |
| 收稿时间： | 5/4/2010 12:00:00 AM |
Effects of Salvianolic Acid B and Paeonol Drug Combination on Rats Isolated Vasorelaxant Activity and Acute Myocardial Ischemia-reperfusion InJury |
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| JIN Kang,KAN Hong-wei,SHI Jing-li,WANG Hai-qing,XU Peng-fu,LIANG Yan,YANG Shi-you and TIAN Jun.Effects of Salvianolic Acid B and Paeonol Drug Combination on Rats Isolated Vasorelaxant Activity and Acute Myocardial Ischemia-reperfusion InJury[J].China Journal of Experimental Traditional Medical Formulae,2010,16(17):197-201. |
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| Authors: | JIN Kang KAN Hong-wei SHI Jing-li WANG Hai-qing XU Peng-fu LIANG Yan YANG Shi-you and TIAN Jun |
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| Institution: | Pharmacological Department, Anhui Institute of Material Medica, Anhui Provincial Center for Drug Safety Pre-clinical Evaluation, The key Lab of Chinese Traditional Medicine Research and Development, Hefei 230022, China; Anhui University School of Life Science, Hefei 230023, China;Pharmacological Department, Anhui Institute of Material Medica, Anhui Provincial Center for Drug Safety Pre-clinical Evaluation, The key Lab of Chinese Traditional Medicine Research and Development, Hefei 230022, China;Pharmacological Department, Anhui Institute of Material Medica, Anhui Provincial Center for Drug Safety Pre-clinical Evaluation, The key Lab of Chinese Traditional Medicine Research and Development, Hefei 230022, China;Pharmacological Department, Anhui Institute of Material Medica, Anhui Provincial Center for Drug Safety Pre-clinical Evaluation, The key Lab of Chinese Traditional Medicine Research and Development, Hefei 230022, China; Anhui University School of Life Science, Hefei 230023, China;Pharmacological Department, Anhui Institute of Material Medica, Anhui Provincial Center for Drug Safety Pre-clinical Evaluation, The key Lab of Chinese Traditional Medicine Research and Development, Hefei 230022, China;Pharmacological Department, Anhui Institute of Material Medica, Anhui Provincial Center for Drug Safety Pre-clinical Evaluation, The key Lab of Chinese Traditional Medicine Research and Development, Hefei 230022, China;Pharmacological Department, Anhui Institute of Material Medica, Anhui Provincial Center for Drug Safety Pre-clinical Evaluation, The key Lab of Chinese Traditional Medicine Research and Development, Hefei 230022, China;Pharmacological Department, Anhui Institute of Material Medica, Anhui Provincial Center for Drug Safety Pre-clinical Evaluation, The key Lab of Chinese Traditional Medicine Research and Development, Hefei 230022, China |
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| Abstract: | |
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| Keywords: | salvianolic acid B paeonol myocardial ischemia-reperfusion inJury |
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