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Inhibition of HIV-1 replication and syncytium formation by synthetic CD4 peptides |
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| Authors: | Yoshio Hayashi Kazuyoshi Ikuta Nobutaka Fujii Kunio Ezawa Shiro Kato |
| Institution: | (1) Department of Pathology, Research Institute for Microbial Diseases, Osaka University, Suita, Osaka;(2) Laboratory of Biochemistry, The Calpis Food Industry Co., Ltd., Sagamihara, Kanagawa;(3) Faculty of Pharmaceutical Science, Kyoto University, Sakyo-ku, Kyoto, Japan |
| Abstract: | Summary Only one peptide of CD4 (amino acid residues 70–132) among 16 synthetic peptide fragments selectively inhibited HIV-1 replication and HIV-1-induced syncytium formation. Several smaller peptides within this region did not show any activity, except for the peptide (86–132) which showed somewhat lower activity. |
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