| JWA as a functional molecule to regulate via MAPK cascades and F-actin cancer cells migration cytoskeleton |
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| 引用本文： | Chen, H. R. Bai, J. Ye, J. Liu, Z. L. Chen, R. Mao, W. G. Li, A. P. Zhou, J. W.. JWA as a functional molecule to regulate via MAPK cascades and F-actin cancer cells migration cytoskeleton[J]. 南京医科大学学报(自然科学版), 2007, 27(10): 1114-1114 |
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| 作者姓名： | Chen H. R. Bai J. Ye J. Liu Z. L. Chen R. Mao W. G. Li A. P. Zhou J. W. |
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| 作者单位： | Nanjing Med Univ, Sch Publ Hlth, Dept Mol Cell Biol ＆ Toxicol, Nanjing 210029, Peoples R China. |
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| 摘 要： | Mitogen activated protein kinase （MAPK） cascades are thought to mediate diverse biological functions such as cell growth, differentiation and migration. Activated MAPK may affect microtubule （MT） which is essential for cellular polarity, differentiation and motility. Data in this study show that JWA, a newly identified novel microtubule-associated protein （MAP） was essential for the rearrangement of F-actin cytoskeleton and activation of MAPK cascades induced by arsenic trioxide （As2O3） and phorbol ester （PMA）. Over-expression of JWA alone in HeLa, B16 and HCCLM3 cancer cells effectively inhibited cellular migration, whereas, cellular migration was significantly accelerated when cells were deficient in JWA expression. The mechanism underlying these phenomena might be due to JWA affected F-actin rearrangement. Furthermore, JWA deficiency blocked anti-migratory effect produced by As2O3 but enhanced the migratory effect initiated by PMA in HeLa cells.
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| 关 键 词： | JWA基因 白血病 分裂素相关蛋白激酶 细胞骨架 肿瘤转移 |
JWA as a functional molecule to regulate via MAPK cascades and F-actin cancer cells migration cytoskeleton |
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| Abstract: | |
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| Keywords: | cell migration MAPK JWA gene, signal transduction actin cytoskeleton focal adhesion kinase microtubule-associated protein acute promyelocytic leukemia breast epithelial-cells induced up-regulation alzheimer-like state nf-kappa-b tyrosine phosphorylation arsenic trioxide signal-transduction |
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