Inflammatory bowel disease |
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| Authors: | Richard HansenFiona Louise Cameron Georgina Louise HoldEmad Munir El-Omar Richard Kay Russell |
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| Affiliation: | Richard Hansen MB ChB MRCPCH is a Clinical Lecturer in Child Health at the University of Aberdeen, Royal Aberdeen Children’s Hospital, Foresterhill, Aberdeen AB25 2ZG, UK. Conflicts of interest: none; Fiona Louise Cameron MB ChB BMSc MRCPCH is a Speciality Registrar in Paediatrics in the Department of Paediatrics, Raigmore Hospital, Perth Road, Inverness IV2 3UJ, UK. Conflicts of interest: none; Georgina Louise Hold BSc(Hons) PhD is a Senior Research Fellow in the Gastrointestinal Research Group, University of Aberdeen, Division of Applied Medicine, Institute of Medical Sciences, Foresterhill, Aberdeen AB25 2ZD, UK. Conflicts of interest: none; Emad Munir El-Omar BSc(Hons) MB ChB MD(Hons) FRCP(Edin) FRSE is a Professor of Gastroenterology in the Gastrointestinal Research Group, University of Aberdeen, Division of Applied Medicine, Institute of Medical Sciences, Foresterhill, Aberdeen AB25 2ZD, UK. Conflicts of interest: none; Richard Kay Russell MB ChB MRCPCH PhD is a Consultant Paediatric Gastroenterologist in the Department of Paediatric Gastroenterology, Hepatology and Nutrition, Royal Hospital for Sick Children, Dalnair Street, Glasgow G3 8SJ, UK. Conflicts of interest: none |
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| Abstract: | Inflammatory bowel disease (IBD) describes a heterogeneous group of chronic inflammatory diseases of the gastrointestinal tract, of which Crohn’s disease and ulcerative colitis are the most common diagnoses. About a quarter of IBD presents in childhood, and the phenotype seen involves a wider disease distribution in both Crohn’s and ulcerative colitis than seen in adult-onset disease. The incidence of IBD appears to be rising and although we understand more about the genetic, immunological and environmental contributors to aetiology, we do not yet fully understand this rise. In paediatric practice, IBD and in particular Crohn’s disease, often results in impaired weight gain, poor linear growth and delayed puberty. Multiple treatment modalities exist for IBD from longstanding treatments such as steroids and immunosuppressants to modern, targeted therapies such as infliximab. This review discusses the current state of the art of clinical practice in relation to paediatric IBD. |
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| Keywords: | children Crohn&rsquo s disease inflammatory bowel disease treatment ulcerative colitis |
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