TNF-R1 as a first trimester marker for prediction of pre-eclampsia |
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| Authors: | Sammya Bezerra Maia e Holanda Moura Felicity Park Padma Murthi Wellington P. Martins Stefan C. Kane Paul Williams |
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| Affiliation: | 1. School of Medicine, University of Fortaleza (UNIFOR), Ceará, Brazil,;2. Department of Public Health, State University of Ceará, Fortaleza, Ceará, Brazil,;3. Department of Perinatal Medicine, Royal Women's Hospital, Melbourne, Victoria, Australia,;4. Central Clinical School, University of Sydney, Sydney, New South Wales, Australia,;5. Northwest Academic Centre, University of Melbourne, Victoria, Australia,;6. Department of Obstetrics and Gynecology, Ribeir?o Preto Medical School, University of S?o Paulo, Ribeir?o Preto, S?o Paulo, Brazil,;7. Department of Perinatal Medicine, Royal Women's Hospital, Melbourne, Victoria, Australia,;8. Department of Obstetrics and Gynaecology, University of Melbourne, Victoria, Australia, |
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| Abstract: | Objective: To examine whether the maternal serum concentration of the soluble receptor-1 of tumor necrosis factor-α (TNF-R1) at 11–13?+?6 weeks of gestation is a predictor of development of pre-eclampsia (PE).Methods: This is a nested case–control study in which the concentration of TNF-R1 at 11?+?0 to 13?+?6 weeks was measured in 426 pregnant women in the first trimester. TNF-R1 values were expressed as multiples of the median (MoM) adjusted for maternal factors. The distributions of log TNF-R1 MoM in the control group and hypertensive disorders (early-PE [ePE], late-PE [lPE] and gestational hypertension [GH]) groups were compared. Logistic regression analysis was used to determine whether maternal factors, TNF-R1 or their combination make a significant contribution to the prediction of PE. Screening performance was determined by analysis of receiver–operating characteristics curves.Results: Median concentration of TNF-R1 (ng/ml) was higher in ePE (2.62?±?0.67), lPE (2.12?±?0.56) and GH (2.19?±?0.45) compared to controls (2.04?±?0.42), p?=?0.001. Logistic regression analysis demonstrated that the addition of TNFR-1 to maternal factors did not make a significant contribution to the prediction of PE.Conclusions: The maternal serum TNF-R1 concentration at 11–13?+?6 weeks of gestation was increased in pregnancies which developed hypertensive disorders, however, the addition of TNFR-1 did not improve the detection rate of these conditions compared with maternal factors alone. |
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| Keywords: | Biomarkers hypertension obstetrics pregnancy pregnancy-induced screening |
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