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Perinatal infection and hypoxic-ischemic encephalopathy: a pilot study |
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| Authors: | Amaia Cilla Juan Arnaez Joaquín Suarez Gregoria Megias María Cabrerizo Alfredo Garcia-Alix |
| Affiliation: | 1. Department of Pediatrics, amaiacilla@gmail.com;3. Department of Neonatology, and;4. Department of Microbiology, Burgos University Hospital, Burgos, Spain,;5. National Centre of Microbiology, Instituto de Salud Carlos III, Madrid, Spain, and;6. Department of Neonatology, Hospital Sant Joan de Deu, Barcelona, Spain |
| Abstract: | Recent studies suggest a synergic effect of infection and hypoxia-ischemia in the causation of perinatal brain damage. We conducted a prospective pilot study on the presence of infection in hypoxic-ischemic encephalopathy (HIE), focusing on neurotropic viruses. Sixteen newborns with HIE were included in the study. There were no confirmed cases of viral infection. There was a case of bacterial early onset sepsis and four cases of suspected sepsis due to clinical and/or analytical signs, but with negative cultures. Our results do not support universal screening for viral infection in cases of HIE. |
| Keywords: | Asphyxia C reactive protein infection neurological damage newborn virus |