The effective combination therapy against human osteosarcoma: doxorubicin plus curcumin co-encapsulated lipid-coated polymeric nanoparticulate drug delivery system |
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| Authors: | Lin Wang WeiGuo Wang Ze Rui |
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| Institution: | 1. Department of Orthopaedics, Shandong Provincial Hospital Affiliated to Shandong University, Ji’nan, P.R. China,;2. Department of Orthopaedics, Affiliated Hospital of Taishan Medical University, Taian, P.R. China, and;3. Department of Orthopaedics, General Hospital of Ji’nan Military Command, Ji’nan, P.R. China;4. Department of Orthopaedics, Affiliated Hospital of Taishan Medical University, Taian, P.R. China, and |
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| Abstract: | Objective: To overcome both the dose-limiting side effects of conventional chemotherapeutic agents and the therapeutic failure incurred from multidrug resistant (MDR) in osteosarcoma (OS), biodegradable lipid-coated polymeric nanoparticles (LPNs) were explored for the loading of doxorubicin (DOX) and curcumin (CUR).Methods: DOX plus CUR co-encapsulated LPNs (DOX?+?CUR LPNs) of mixed lipid monolayer shell and biodegradable polymer core were prepared. The cytotoxicity effect of DOX?+?CUR LPNs, single drug loaded LPNs, and free drug solutions were evaluated on human OS cell line KHOS cells and mice KHOS cells xenograft in vivo.Results: DOX?+?CUR LPNs displayed a curative effect on OS cell lines than the free drug counterparts. Also, best anti-OS effects were observed on the animal model compared with other groups tested.Conclusion: This promising dual drugs co-encapsulated lipid-coated polymeric nanoparticulate drug delivery system enhanced the cell delivery and activity of drugs against human OS cancer cell lines and in cancer bearing mice. This research may offer new options for the treatment of OS. |
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| Keywords: | Co-encapsulated combination therapy drug delivery system human osteosarcoma lipid-coated polymeric nanoparticle |
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