Tenascin C levels in patients with mild and severe preeclampsia |
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| Authors: | Ugur Orak Ebru Celik İsmail Demirel Remzi Atilgan Suleyman Aydin |
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| Affiliation: | 1. Department of Obstetrics and Gynecology, Firat Medical Center, School of Medicine, Firat University, Elazig, Turkey,;2. Department of Obstetric and Gynecology, Special Medical Park Hospital, Elazig, Turkey,;3. Department of Anesthesia and Reanimation, and;4. Department of Biochemistry, Firat University, Elazig, Turkey |
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| Abstract: | Objective: To determine the serum tenascin-C (TN-C) levels in cases with mild and severe preeclampsia.Methods: Pregnant women were divided into three groups, namely healthy pregnants (Group 1, n?=?20), pregnants with mild preeclampsia (Group 2, n?=?20) and pregnants with severe preeclampsia (Group 3, n?=?20). The groups were formed so as to match each other in terms of gestational week. From each pregnant woman, pre- and post-delivery blood samples were obtained to measure serum TN-C levels. The data were evaluated using the Kruskall–Wallis variance analysis. For the obtained values of p?p value of Results: In Groups 1, 2 and 3, the prepartum TN-C levels were 5.02?±?0.4?µg/ml, 12.8?±?2.9?µg/ml and 33.8?±?11.7?µg/ml, and in the postpartum TN-C levels were 4.7?±?0.1?µg/ml, 11.7?±?1.8?µg/ml and 50.6?±?33.8?µg/ml, respectively. There was a significant difference between the groups in terms of the prepartum and postpartum TN-C levels (p?U [MWU] test). There was also a significant difference in the prepartum TN-C levels between Groups 2 and 3 (p?Conclusions: The prepartum and postpartum TN-C levels were significantly higher in mild and severe preeclampsia than those in healthy pregnants. |
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| Keywords: | Cytokine preeclampsia tenascin-C |
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