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Placenta-related complications in women carrying a foetus with congenital heart disease |
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| Authors: | Aina Ruiz Queralt Ferrer Olga Sánchez Irene Ribera Silvia Arévalo Onofre Alomar |
| Affiliation: | 1. Department of Obstetrics, Maternal-Foetal Medicine Unit, Vall d’Hebron University Hospital, Universitat Autònoma De Barcelona, Barcelona, Spain,;2. Department of Paediatric Cardiology, Vall d’Hebron University Hospital, Universitat Autònoma De Barcelona, Barcelona, Spain,;3. Maternal and Child Health and Development Network II (SAMID II) RD12/0026, Institute of Health Carlos III, Madrid, Spain, and;4. Biochemistry and Molecular Biology Research Centre for Nanomedicine, Vall D’Hebron Research Institute, Barcelona, Spain |
| Abstract: | Introduction: Recent studies pointed to an intrinsically angiogenic imbalance in CHD in the maternal and foetal circulation suggestive of impaired placentation.Objectives: To assess whether pregnant women with a CHD foetus are at greater risk of placenta-related complications.Methods: Perinatal results of women with a CDH foetus were compared with those of a non-selected population followed up at our centre. Multiple pregnancies and chromosomal abnormalities were excluded from the analysis.Results: About 279 pregnancies with CHD foetuses were included. Mothers were classified in three groups according to the foetal cardiac defect: 104 (37.3%) atrioventricular defect, 102 (36.5%) conotruncal anomalies and 73 (26.2%) left-ventricular outflow tract obstruction. A significantly higher incidence of pre-eclampsia was observed in the CHD group compared with the normal population (5.7% versus 1.2% p?Conclusions: Women carrying a foetus with CHD have a high risk of pre-eclampsia and intrauterine growth restriction. The relationship between CHD and placenta-related complications could be an encouraging topic for future research. |
| Keywords: | Congenital heart defects intrauterine growth restriction pre-eclampsia |