Superior vena cava flow and intraventricular haemorrhage in extremely preterm infants |
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| Authors: | Sarah Bates David Odd Karen Luyt Paul Mannix Richard Wach David Evans |
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| Institution: | 1. Neonatal Intensive Care Unit, Southmead Hospital, North Bristol NHS Trust, Bristol, UK, and drsarahbates@doctors.org.uk;3. Neonatal Intensive Care Unit, Southmead Hospital, North Bristol NHS Trust, Bristol, UK, and;4. School of Clinical Science, University of Bristol, Bristol, UK;5. School of Clinical Science, University of Bristol, Bristol, UK;6. Neonatal Intensive Care Unit, Southmead Hospital, North Bristol NHS Trust, Bristol, UK, and |
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| Abstract: | Objective: To evaluate the relationship between superior vena cava flow (SVCF) measurements within the first 24?h of life, and development of intraventricular haemorrhage (IVH) in extremely preterm infants.Study design: Single centre retrospective cohort study of 108 preterm infants born less than 28 weeks’ gestation. Main outcome measure was degree of IVH at day 7 postnatal age.Results: The mean GA of the study group was 25.4 weeks. Mean SVCF was lower (75?ml/kg/min) in infants later diagnosed with IVH (n?=?46) compared to infants, who did not develop IVH (87.7?ml/kg/min, p?=?0.055). PDA diameter was inversely associated with SVCF (p?=?0.024) and reversal of flow in the descending aorta (p?=?0.001). Sensitivity analysis did not confirm an independent association of SVCF with development of IVH OR 0.990 (0.978–1.002), p?=?0.115].Conclusion: Our study describes early SVCF in extremely preterm infants is associated with the extent of ductal shunting, but insensitive in predicting IVH. |
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| Keywords: | Cardiac imaging techniques colour Doppler echocardiography extremely preterm infant intraventricular haemorrhage superior vena cava flow |
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