Carbonic anhydrase IX deposits are associated with increased ascending aortic dilatation |
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| Authors: | Eetu Niinimaki Petteri Muola Seppo Parkkila Ivana Kholová Hannu Haapasalo Silvia Pastorekova |
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| Affiliation: | 1. School of Medicine, University of Tampere, Tampere, Finland;2. Department of Pathology, Fimlab Laboratories, Tampere University Hospital and Tampere University Medical School, Tampere, Finland;3. Department of Pathology, Fimlab Laboratories, Tampere University Hospital and Tampere University Medical School, Tampere, Finland;4. Department of Molecular Medicine, Institute of Virology, Slovak Academy of Sciences, Bratislava, Slovak Republic |
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| Abstract: | Objectives. Carbonic anhydrase IX (CA IX) expression is induced by local hypoxia. We studied whether CA IX deposits associate with ascending aortic dilatation. Design. Aortic wall histology, CA IX expression, presence of leukocytes, plasma cells, macrophages, endothelial cells, smooth muscle cells, cell proliferation, elastin and collagen were studied in histological specimens collected from 30 patients who underwent surgery for ascending aorta. The samples were grouped according to presence of CA IX deposits. Results. Twenty out of 30 patients had CA IX-positive deposits within the adventitia, whereas 10 specimens remained negative. Adventitial inflammation was increased in CA IX-positive samples as compared with CA IX-negative ones (p?Conclusions. Positive CA IX staining in certain aortic specimens suggests that increased CA activity may contribute to ascending aortic dilatation. |
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| Keywords: | Ascending aortic dilatation CA IX inflammation |
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