Effects of vitamin D supplementation as an adjuvant therapy in coronary artery disease patients* |
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Authors: | Zhaoke Wu Ting Wang Shenshen Zhu |
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Affiliation: | 1. Department of Gerontology, The Second Affiliated Hospital of Zhengzhou University at Zhengzhou, Zhengzhou, China;2. Department of Gerontology, Shanxi Provincial People's Hospital at Xi'an, Xi’an, China |
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Abstract: | Objectives: Low vitamin D status has been shown to be associated with coronary artery disease. We planned to research the effects of vitamin D3 supplementation on the severity of coronary artery disease. Design: We investigated the effect of 0.5 μg vitamin D3 per day in a randomized, placebo-controlled, double-blind study in 90 stable coronary artery disease patients residing in Beijing. Coronary angiography was performed before and after 6 months of treatment that took place between January and June. 25-Hydroxyvitamin D was measured by chemiluminescence assay. Coronary artery disease severity was assessed by using the SYNTAX scores. Results: In vitamin D supplementation group, there was a significant increase in mean 25-hydroxyvitamin D levels from baseline (19.9?±?9.8 ng/ml) to 6 months (35.8?±?12.1 ng/ml; p?0.001). At 6 months, the primary end point, a difference in the fall of SYNTAX score between the groups was ?2.5 (95% CI ?5.1 to ?0.5; p?0.001) under intention to treat analysis. Compared with the control group, patients treated with vitamin D3 also had greater decreases in high sensitivity C-reactive protein and renin-angiotensin system activity (p?0.05). Conclusions: Vitamin D supplementation has beneficial effects on coronary artery disease; it can be an adjuvant therapy for patients with coronary artery disease. |
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Keywords: | Adjuvant therapy coronary artery disease supplementation SYNTAX scores vitamin D |
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