Acute corneal toxicity of latanoprost with different preservatives |
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| Authors: | Masafumi Uematsu Yasser Helmy Mohamed Naoko Onizuka Ryotaro Ueki Daisuke Inoue Azusa Fujikawa |
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| Affiliation: | 1. Department of Ophthalmology and Visual Sciences, Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki, Japan, uematsu1124@outlook.jp;3. Department of Ophthalmology and Visual Sciences, Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki, Japan,;4. Department of Ophthalmology, EL-Minia University Hospital, EL-Minia, Egypt, and;5. Department of Ophthalmology and Visual Sciences, Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki, Japan, |
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| Abstract: | Purpose: To investigate the corneal toxicity of Xalatan and three latanoprost generics using transepithelial electrical resistance (TER) and scanning electron microscopy (SEM).Methods: Corneal TER changes after a 60-s exposure to Xalatan (latanoprost 0.005% preserved with 0.02% BAC), and latanoprost generics (Latanoprost PF BAC free, Latanoprost Nitten SB containing sodium benzoate and Latanoprost Towa containing 0.01% BAC with sodium chloride polysorbate 80 as additive) were measured in living rabbits. Corneal damage was also examined by SEM. Hank’s balanced salt solution (HBSS) was used as a control.Results: There was a significant decrease in the corneal TER after exposure of the cornea to Xalatan (p?p?p?p?Conclusion: The corneal toxicity of Xalatan is greater than that of latanoprost generics. Xalatan contains 0.02% BAC, which may be responsible for the corneal toxicity. |
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| Keywords: | Benzalkonium chloride cornea generics latanoprost transepithelial electrical resistance Xalatan |
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