Role of antioxidants in gestational diabetes mellitus and relation to fetal outcome: a randomized controlled trial |
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| Authors: | Ahmed M. Maged Haitham Torky Mona A. Fouad Sherine H. GadAllah Nevien M. Waked Ahmed S. Gayed |
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| Affiliation: | 1. Obstetrics and Gynecology Department, Kasr Aini Hospital Cairo University, Cairo, Egypt, prof.ahmedmaged@gmail.com;3. Obstetrics and Gynecology Department, 6th October University, Cairo, Egypt,;4. Obstetrics and Gynecology Department, Kasr Aini Hospital Cairo University, Cairo, Egypt,;5. Pediatric Department, 6th October University, Cairo, Egypt, and |
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| Abstract: | Objective: To examine the effect of antioxidant administration on the oxidative parameters in both blood and placental tissue and its relation to fetal outcome in women with GDM.Patients and methods: Two-hundred pregnant women with gestational diabetes mellitus (GDM) were randomized into 2 groups, Group1 received 1 gram L-ascorbic acid per day and Group2 received placebo.Results: The use of antioxidants significantly lower the needed insulin dose for blood sugar control (25.6?±?20.3 versus 40.5?±?23.7, respectively). In placental tissue homogenates, glutathione (GSH) was 49.6?±?5.9 versus 62.34?±?4.99, malondialdahyde (MDA) was 165.7?±?9.2 versus 264.15 ±?12, superoxide dismutase (SOD) was 0.3?±?0.3 versus 0.054?±?0.16 while catalase (CAT) was 14.06?±?2.4 versus 15.52?±?3.97 and glutathione peroxidase (GPx) was 14?±?4.1 versus 26.3?±?4.26 in antioxidant group compared to the control group (p?p p?p <0.05). The neonates NICU admission was lower in antioxidant group (5 versus 11) (p <0.05).Conclusion: The use of antioxidants markedly reverses the oxidative stresses in women with GDM with marked improvement on neonatal outcome. |
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| Keywords: | Antioxidants fetal outcome gestational diabetes oxidative stress |
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