Weight gain in gestational diabetes: the effect of treatment modality |
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Authors: | Lois E. Brustman Oded Langer Brianne Bimson Sophia Scarpelli Manal El Daouk |
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Affiliation: | 1. Department of Obstetrics and Gynecology, St. Luke's-Roosevelt Hospital Center, New York, NY, USALBrustma@chpnet.org;3. Department of Obstetrics and Gynecology, St. Luke's-Roosevelt Hospital Center, New York, NY, USA |
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Abstract: | Objective: To evaluate treatment effectiveness (diet alone, insulin or glyburide) on maternal weight gain in gestational diabetes (GDM).Methods: GDM patients were treated with diet alone, insulin or glyburide. Weight gain was stratified into: prior to GDM diagnosis, from diagnosis to delivery and total pregnancy weight gain. Good glycemic control was defined as mean blood glucose ≤105?mg/dl and obesity as Body Mass Index (BMI)?≥?30?kg/m2, overweight BMI 25–29?kg/m2 and normal 25?kg/m2.Results: Total weight gain was similar in all the treatment groups. Two-thirds of weight gain occurred prior to diagnosis (diet 85%, insulin 67% and glyburide 78%). Post-diagnosis, patients on diet alone gained less weight than those on insulin or glyburide (p?0.001); insulin-treated patients showed greater weight gain than glyburide-treated patients (p?0.001). Patients on diet with good glycemic control showed less weight gain after diagnosis than patients on insulin or glyburide (2.8?±?13, 6.6?±?10, 5.2?±?7.9 lbs, respectively, p?0.02). Poorly-controlled patients, regardless of treatment, had similar patterns of weight gain throughout pregnancy.Conclusion: Patterns of maternal weight gain in GDM pregnancies are associated with treatment modality and level of glycemic control. |
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Keywords: | GDM glyburide glycemic control insulin weight gain in pregnancy |
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