High bisphenol A (BPA) concentration in the maternal,but not fetal,compartment increases the risk of spontaneous preterm delivery |
| |
Authors: | Faranak Behnia Morgan Peltier Darios Getahun Cheryl Watson George Saade |
| |
Institution: | 1. Department of Obstetrics and Gynecology, University of Texas Medical Branch at Galveston, TX, USA,;2. Department of Biomedical Research,;3. Department of Obstetrics and Gynecology, Winthrop University Hospital, Mineola, NY, USA,;4. Department of Research and Evaluation, Kaiser-Permanente Southern California, Pasadena, CA, USA, and;5. Department of Biochemistry &6. Molecular Biology, University of Texas Medical Branch at Galveston, TX, USA |
| |
Abstract: | Objective: The objective of this study is to determine if BPA exposure, as measured by maternal plasma (MP) and amniotic fluid (AF) BPA concentrations is associated with an increased risk of spontaneous preterm birth (PTB) and preterm premature rupture of membranes (pPROM).Methods: In this nested case–control study, MP samples from women in term labor (n?=?30), preterm labor that ended with preterm delivery (n?=?25), or who had pPROM (n?=?30) and amniotic fluid samples from term labor (n=?45), preterm labor (n?=?60), and pPROM (n?=?35) were assayed for BPA by enzyme immunoassay.Results: BPA was detectible in 100% of MP and AF samples. Women with MP BPA concentrations in the fourth quartile were at increased risk of PTB (cOR?=?4.12, 95% CI?=?1.32–12.87; aOR?=?4.78, 95% CI?=?1.14–20) but not pPROM. High (fourth quartile) AF BPA values also tended to increase the risk of pPROM (cOR?=?2.47, 95% CI?=?0.96–6.37) but results were not statistically significant.Conclusions: Increased BPA concentration is associated with an increased risk for PTB or pPROM depending on the maternal–fetal compartment(s) affected. High MP plasma BPA concentrations are associated with PTB with intact membranes but high AF BPA concentrations may weakly be associated with pPROM. |
| |
Keywords: | Amniotic fluid bisphenol A maternal plasma preterm birth |
|
|