Effect of fruit vinegars on liver damage and oxidative stress in high-fat-fed rats |
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| Authors: | Asma Bouazza Arezki Bitam Malek Amiali Abdenour Bounihi Lyece Yargui Elhadj Ahmed Koceir |
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| Affiliation: | 1. Bioenergetics and Intermediary Metabolism Laboratory, Department of Biological Sciences and Physiology, FSB, University of Sciences and Technology Houari Boumediene (USTHB), Algiers, Algeria, bouazza-asma@hotmail.fr;3. Bioenergetics and Intermediary Metabolism Laboratory, Department of Biological Sciences and Physiology, FSB, University of Sciences and Technology Houari Boumediene (USTHB), Algiers, Algeria,;4. Department of Food Technology and Human Nutrition, Ecole Nationale Supérieure Agronomique, ElHarrach, Algiers, Algeria, and;5. Department of Food Technology and Human Nutrition, Ecole Nationale Supérieure Agronomique, ElHarrach, Algiers, Algeria, and;6. Bioenergetics and Intermediary Metabolism Laboratory, Department of Biological Sciences and Physiology, FSB, University of Sciences and Technology Houari Boumediene (USTHB), Algiers, Algeria,;7. Department of Medicine, Faculty of Health Sciences, Central Biochemistry Laboratory, Mustapha Bacha Hospital, Algiers, Algeria |
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| Abstract: | Context: Vinegar has long been used as a condiment and a traditional medicine worldwide.Objective: The current study investigates the antioxidant effect of three types of fruit vinegars (FV) namely pomegranate [Punica granatum L. (Punicaceae)], prickly pear [Opuntia ficus-indica (L.) Mill. (Cactaceae)], and apple [Malus domestica Borkh. (Rosaceae)] vinegars in high-fat diet (HFD)-induced hyperlipidemic Wistar rats.Materials and methods: Fifty male Wistar rats were divided into five groups; HFD (80?cal/d) fed rats were orally dosed with fruit vinegars (7?ml/kg) once daily for 28?weeks. At the end of the experiment, lipid profile, lipid peroxidation products, antioxidant enzymes, and trace elements were assessed in serum. In addition, a liver histopathological study was performed.Results: HFD showed a significant increase (p?≤?0.05) in lipid profile and TBARS levels when compared with normal control. Daily oral administration of FV normalized various biochemical, metabolic, and histopathological changes. However, pomegranate vinegar exhibited a very significant (p?≤?0.001) reduction in lipid profile levels (total cholesterol: 165%, triglycerides: 68%, LDL-c: 76%, and atherogenic index: 80%), whereas an increase in antioxidant status (SOD: 7-fold, GPx: 4.81-fold, GRx: 1.66-fold, and TAS: 3.45-fold) when compared with hyperlipidemic control. Histopathological examinations also confirmed the protective effects of pomegranate vinegar against lipid accumulation and the improvement of hepatic lesions.Discussion and conclusion: The fruit vinegars regulate lipid metabolism and decrease liver damage in high-fat fed rats as shown in this study. |
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| Keywords: | Antihyperlipidemic effect antioxidant effect apple pomegranate prickly pear |
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