Nephro-protective potential of Morus alba,a prospective experimental study on animal models |
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| Authors: | Naveed Ullah Mir Azam Khan Salimullah Khan Habib Ahmad Afzal Haq Asif Taous Khan |
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| Affiliation: | 1. Department of Pharmacy, University of Swabi, Swabi, KPK, Pakistan, naveedjia@yahoo.com dr.naveedullah@uoswabi.edu.pk;3. Department of Pharmacy, University of Malakand, Chakdara, Pakistan,;4. Department of Pharmacy, University of Swabi, Swabi, KPK, Pakistan,;5. Department of Genetics, Hazara University Mansehra, Dhodial, Pakistan,;6. College of Clinical Pharmacy, King Faisal University, Al-Ahsa, Saudi Arabia, and;7. Department of Pharmaceutical Sciences, COMSATs Abbottabad, Abbottabad, Pakistan |
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| Abstract: | Context: Morus alba L. (Moraceae) is traditionally used for the treatment of urinary incontinency due its strong diuretic properties.Objective: The present study explores the renal protective effects of M. alba, due to its free radical scavenging properties, in order to provide experimental evidence for its established use.Materials and methods: Ethanolic extract (200?mg/kg/d) derived from M. alba fruit was employed in rabbits as a co-therapy (GM-al) with gentamicin (80?mg/kg/d) for a period of 3?weeks. Biochemical kidney functioning parameters, urinary isozymes, and histopathological examination were performed.Results: The results showed that ethanol extract of Morus alba L. prevented alterations in serum creatinine (4.02?±?0.14, p?p?p?Discussion and conclusions: The co-administration of M. alba with gentamicin prevented renal functioning alterations expected with the use of gentamicin alone. Therefore, it can be concluded that M. alba to protect from kidney damage, which may be because of its free radical scavenging and diuretic properties. |
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| Keywords: | Gentamicin medicinal plant nephroprotection toxicity |
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