A novel protocol for postpartum magnesium sulphate in severe pre-eclampsia: a randomized controlled pilot trial |
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Authors: | Waleed El-Khayat Adel Atef Sahar Abdelatty Ali El-semary |
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Affiliation: | 1. Department of Obstetrics and Gynecology, Faculty of Medicine, Cairo University, Cairo, Egypt and waleed_elkhyat@yahoo.com waleedelkhayat@kasralainy.edu.eg;3. Department of Obstetrics and Gynecology, Faculty of Medicine, Cairo University, Cairo, Egypt and;4. Department of clinical and chemical pathology, Faculty of medicine, Cairo University, Cairo, Egypt |
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Abstract: | Objective: Magnesium sulphate is the preferred anticonvulsant used to prevent the development of fits in severe pre-eclampsia; we aim to compare between three different protocols of postpartum magnesium sulphate in the effectiveness of preventing the development of fits in severe pre-eclampsia.Methods: Double-blind randomized controlled pilot trial, done in Cairo university hospital, Cairo, Egypt during 2013–2014, on 240 women with severe pre-eclampsia. Magnesium sulphate intravenous infusion was given in the postpartum period to all the patients, women were randomly allocated to group I (Single loading dose only), group II (12?h abbreviated protocol) or group III (24?h standard protocol) (n?=?80 in each group).Results: There were no significant difference between the three groups as regards the incidence of eclampsia, elevated liver enzymes and low platelets syndrome, maternal ICU admission and; however The incidence of flushing was significantly higher in group III than group II and I (24 [30%] versus 12 [15%] versus 4 [5%]; p?0.001) respectively.Conclusion: The pilot study demonstrates that the single-loading dose of postpartum magnesium sulphate is a promising alternative to the standard and the abbreviated protocol in preventing eclampsia; however, a large clinical trial is necessary to prove this. |
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Keywords: | Abbreviated regimen eclampsia magnesium sulphate pre-eclampsia |
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