Clinical outcomes of frozen-thawed single blastocyst transfer in patients requiring whole embryo freezing |
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Authors: | Qiao-hua He Lu Wang Lin-lin Liang He-long Zhang Cui-lian Zhang Hang-sheng Li |
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Institution: | 1. Department of Obstetrics and Gynecology, The Third Affiliated Hospital of Zhengzhou University, Zhengzhou, China;2. Reproductive Medical Center, Henan Provincial People’s Hospital, Zhengzhou, China;3. Reproductive Medical Center, Henan Provincial People’s Hospital, Zhengzhou, China |
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Abstract: | We compared clinical outcomes amongst frozen-thawed cleavage-stage embryo, double and single blastocyst transfers in patients requiring whole embryo freezing. Data of infertile patients undergoing in-vitro fertilization and embryo transfer (IVF-ET) in our Reproductive Medicine Center from January 2010 to December 2012 were retrospectively analyzed. According to patients’ wishes, patients were divided into cleavage-stage embryo transfer groups (group A, n = 456), double blastocyst transfer group (group B, n = 106), and single blastocyst transfer group (group C, n = 402). We found that the number of frozen embryos was significantly less in groups B and C than in group A (all p < 0.05), but the implantation rate was significantly higher in groups B and C as compared to group A (all p < 0.05). The clinical pregnancy rate and pregnancy rate per included cycle were significantly higher in group B than in groups A and C (all p < 0.05). The multiple pregnancy rate was significantly lower in group C than in groups A and B (all p < 0.05). The rate of early abortion was significantly lower in group C as compared to group A (p < 0.05). The data support the view that it may be the best clinical strategy for patients who require whole embryo freezing and have four or more Day 3 embryos available, to incubate Day 3 embryos into blastocysts, which are then vitrified for elective single blastocyst transfer. |
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Keywords: | Blastocyst frozen-thawed embryo transfer in-vitro fertilization pregnancy rate |
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