Comparing vaginal misoprostol versus Foley catheter plus vaginal isosorbide mononitrate for labor induction |
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Authors: | Waleed El-Khayat Heba Alelaiw Abdallah El-kateb Ali Elsemary |
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Institution: | 1. Department of Obstetrics and Gynecology, Faculty of Medicine, Cairo University, Cairo, Egyptwaleed_elkhyat@yahoo.com waleedelkhayat@kasralainy.edu.eg;3. Department of Obstetrics and Gynecology, Faculty of Medicine, Cairo University, Cairo, Egypt |
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Abstract: | Objective(S): To compare the effectiveness and safety of intra-cervical Foley catheter combined with intra-vaginal isosorbide mononitrate (IMN) versus intra-vaginal misoprostol for cervical ripening and labor induction in pregnant women with unripe cervices.Methods: Open-labeled randomized controlled trial in Cairo university hospital, Cairo, Egypt during 2012–2014. Three hundred and ninety-five pregnant women at term or post-term with an indication for labor induction and unripe cervix were included in the study. The subjects were randomly divided into two groups. Vaginal misoprostol was used in group 1 (n?=?197) and intra-cervical Foley catheter plus vaginal IMN in group 2 (n?=?198). Our main outcome measure was cesarean section rate.Results: Among the 395 included patients there were significantly lower duration of induction of labor (p?<?0.001) in group 1with lower cesarean section rates 22.8% in group 1versus 33.3% in group 2; RR 0.7 (0.6–0.9), (p?=?0.020)]. Whereas the uterine hyperstimulation (p?<?0.001) was significantly higher in group 1. There were no significant differences between both groups as regard patients’ demographic characteristics.Conclusions(s): Vaginal misoprostol is more effective but less safe than Foley catheter combined with vaginal IMN for induction of labor in term and post-term pregnancy. |
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Keywords: | Cervical ripening foley catheter isosorbide mononitrate labor induction misoprostol |
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