盐酸氨溴索预防体外循环术后急性肺损伤的作用与机制

： 目的 研究体外循环手术前使用盐酸氨溴索对体外循环手术后急性肺损伤的保护机制。方法 将80 例体外循环手术病人随机分为4组 (空白对照组以及5、10、20mg/kg盐酸氨溴索组) , 分别给予生理盐水及相应分组剂量盐酸氨溴索，测定术后气道吸取物中磷脂含量及血中SOD，MDA含量。结果 气道吸取物中磷脂含量及血中SOD，MDA含量在实验组与对照组间差异存在统计学意义(P＜0.05)，大剂量盐酸氨溴索组( 20mg/kg) 与中剂量组(10mg/kg)差异无统计学意义（P＞0.05），但与空白对照组、小剂量组(5mg/kg)间差异有统计学意义（P＜0.05）。结论：体外循环手术前使用盐酸氨溴索可以促进肺泡表面活性物质的合成，减轻体外循环手术后急性肺损伤，这种保护作用在一定剂量范围内存在剂量依赖性。

The role of ambroxol in prevention of acute lung injury after cardiopulmonary bypass

【Abstract】 Objective To study the protection mechanism of pretreatment with ambroxol against acute lung injury after cardiopulmonary bypass surgery . Methods 80 cases of cardiopulmonary bypass patients were randomly divided into 4 groups (control group, as well as 5,10,20 mg / kg ambroxol group) were given saline and the corresponding sub-dose ambroxol, determination of alveolar phospholipid content in the tracheal aspirate, serum SOD and MDA content postoperation. Results the phospholipid content of the tracheal aspirate and serum SOD, MDA content in the ambroxol group and control group statistically significant differences (P <0.05 ), high-dose group of ambroxol (20mg/kg) with the middle dose group ( 10mg/kg) was no significant difference (P> 0.05), but with the control group, low-dose group (5mg/kg) were statistically significant differences between (P <0.05 ). Conclusion The use of ambroxol before cardiopulmonary bypass surgery can promote surfactant synthesis and reduce acute lung injury after cardiopulmonary bypass surgery, the protective effect of a certain dose range of memory in a dose-dependent manner.