肝细胞肝癌患者血清AFP—IgM复合物表达水平及其临床意义 |
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引用本文: | 陈连周,彭文兴,罗苑娜,李雯,王东,汪谦.肝细胞肝癌患者血清AFP—IgM复合物表达水平及其临床意义[J].中国临床实用医学,2009,3(10):48-49. |
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作者姓名: | 陈连周 彭文兴 罗苑娜 李雯 王东 汪谦 |
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作者单位: | 广州中山大学附属第一医院,510080 |
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摘 要: | 目的探讨肝细胞肝癌(HCC)患者血清甲胎蛋白-IgM免疫复合物(AFP—IgM)的表达水平及其临床意义。方法应用酶联免疫吸附分析(ELISA)法检测79例HCC患者、20例中度肝硬化患者和30例健康对照者血清中AFP-IgM水平,并进行对比分析。结果AFP-IgM的浓度和阳性率分别为HCC组422.20×10^3AU/L和73%,肝硬化组268.85×10^3AU/L和20%,健康对照组119.71×10^3AU/L1和7%。HCC组阳性率显著高于肝硬化组和健康对照组(分别P〈0.01);Ⅰ期和Ⅱ期HCCAFP-IgM阳性率(分别为89%和88%)高于Ⅲ期(30%,P〈0.05);AFP-IgM的水平与肿瘤分期、大小有关。结论血清AFP-IgM对HCC的早期诊断具有重要意义,有望成为一个有用的辅助诊断HCC的生物标志。
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关 键 词: | 肝细胞肝癌 甲胎蛋白类 免疫球蛋白M |
The expression and significance of serum AFP-IgM immune complexes in hepatocellular carcinoma |
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Institution: | CHEN Lian-zhou,PENG Wen-xing,LUO Yuan-na, et al.(The First Affiliated Hospital of Sun Yat-sen University, Guangzhou 510080, China) |
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Abstract: | Objective To investigate the expression level of AFP-IgM in hepatocellular carcinoma (HCC).Methods The serum AFP-IgM concentrations were detected by ELISA in 79 HCC patients,20 patients affected by liver cirrhosis and 30 healthy controls.Results AFP-IgM concentrations in serum and the positive rate were significantly higher in HCC than that in liver cirrhosis and in healthy controls(P<0.01).The positive rates of AFP-IgM in the stage Ⅰ or Ⅱ(89%,88%)were higher than that of the stage Ⅲ(30%,P<0.05).The serum concentration of AFP-IgM is related to the stage,tumor sizes.Conclusion AFP-IgM was of significance for early diagnosis of HCC,it will hopefully be a useful biological marker for the diagnosis of HCC. |
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Keywords: | Hepatocellular carcinoma Alpha-fetoproteins Immunoglobulin M |
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