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| 兔下肢局部注射氟尿嘧啶脂质体的淋巴靶向示踪 | |
| 引用本文： | 李小海,何建行,陈萍,魏献忠,张贵平,花宁.兔下肢局部注射氟尿嘧啶脂质体的淋巴靶向示踪[J].山东大学学报(医学版),2010,48(1):78-81. |
| 作者姓名： | 李小海 何建行 陈萍 魏献忠 张贵平 花宁 |
| 作者单位： | 1. 呼吸疾病国家重点实验室广州呼吸疾病研究所广州医学院第一附属医院胸心外科,广州,510120 2. 广州医学院第一附属医院核医学科,广州,510120 3. 广州医学院药理教研室,广州,510182 4. 中国原子能科学院广州办事处,广州,510087 |
| 基金项目： | 广东省科技厅前沿探索类项目资助课题(99B06701G) |
| 摘 要： | 目的 通过同位素示踪技术探讨氟尿嘧啶脂质体(FL)的局部淋巴结靶向性,为恶性肿瘤的局部淋巴靶向化疗提供依据.方法 将6只兔双侧第一趾蹼皮下注射~(99m)Tc-FL后,用SPECT连续动态示踪30min或60min.然后在8h内静态显像监测FL的淋巴流向途径,并探测1、3、6h时在注射区、胭窝淋巴结、盆腔淋巴结群、后腹膜淋巴结群、乳糜池等局部淋巴结区域的闪烁计数率(%).结果 动态示踪、静态监测见注射区~(99m)Tc-FL缓慢靶向流至局部淋巴结而显影,局部淋巴结高浓度积聚,而其余组织浓度很低.在注药后1、3、6h 3组间注射区或局部淋巴结的闪烁计数率比较,差异有统计学意义(P<0.05),注射区的闪烁计数率逐渐下降,而局部淋巴结则逐渐上升;各组内局部淋巴结与其余组织(注射区除外)的闪烁计数率比较差异有统计学意义(P<0.05),局部淋巴结的闪烁计数率明显高于其余组织.结论 FL具有局部淋巴靶向性和富集性,并不直接进入血液循环,提示恶性肿瘤局部淋巴靶向化疗具有可行性. |
| 关 键 词： | 肿瘤 脂质体 淋巴结 放射性核素显像 |
| 收稿时间： | 2009-07-07 |
Lymphoscintigraphy in regional lymph nodes on lower extremities of rabbits using 99m-Tc-injection of liposome of 5-fluorouracil by hypodermicinjection |
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| LI Xiao-hai,HE Jian-xing,CHEN Ping,WEI Xian-zhong,ZHANG Gui-ping,HUA Ning.Lymphoscintigraphy in regional lymph nodes on lower extremities of rabbits using 99m-Tc-injection of liposome of 5-fluorouracil by hypodermicinjection[J].Journal of Shandong University:Health Sciences,2010,48(1):78-81. | |
| Authors: | LI Xiao-hai HE Jian-xing CHEN Ping WEI Xian-zhong ZHANG Gui-ping HUA Ning |
| Institution: | LI Xiao-hai1,HE Jian-xing1,CHEN Ping2,WEI Xian-zhong2,ZHANG Gui-ping3,HUA Ning4 (1. The State Key Laboratory of Respiratory Diseases,The Department of Thoracic Surgery,Guangzhou Institute of Respiratory Diseases,The First Affiliated Hospital of Guangzhou Medical College,Guangzhou 510120,China,2. The Department of Nucler Medicine,3. The Teaching , Research Office of Pharmacology,Guangzhou Medical College,Guangzhou 510182,Ch... |
| Abstract: | Objective To investigate lymphoscintigraphy and enrichment of 99mTc-FL in regional lymph nodes by SPECT to provide a basis for the regional lymph system targeted chemotherapy of malignant tumors. Methods 6 rabbits were hypodermically injected with 0.5 mCi of 99m Tc-FL in the first medial web on the dorsum of lower extremities. Lymphatic flow imaging was dynamically traced by SPECT in 30 or 60 minutes after injection. The diffusion and gathering of the radioisotope in the regional lymphatic vessels and lymph... |
| Keywords: | Neoplasms Liposomes Lymph nodes Radionuclide imaging |
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